Review: Neuroprotective effect of herbal plant extracts against Parkinson's disease
Abstract
Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by the
loss of dopaminergic neurons and the exist of Ƚ-synuclein aggregates in the substantia nigra pars
compacta (SNpc). Among the various types of neuroprotective therapy, natural products are potential
therapeutic agents for PD.
Objective: The aim of this study is to describe the neuroprotective effect of herbal plant extracts
against Parkinson's Disease (PD).
Method: The search strategy was carried out on electronic databases, namely Google Scholar,
ScienceDirect, and PubMed®. There are 111 scientific journals that have been filtered into 20
scientific journals which are international journals published in the last 5 years (2015-2020). The
keywords used include "Parkinson's Disease", "Neuroprotective Effects", Dz dzǡ "Plant
Extracts", Dz dz and "Parkinson's Disease Model".
Results: Several experimental studies have shown the neuroprotective ability of various plant
extracts to protect against neurotoxicity, through several neuroprotective pathways including
antioxidant activity, anti-inflammatory activity, and antiapoptotic activity.
Conclusion: Herbal plant extracts have been shown to have strong neuroprotective effects, making
them as potential drug candidates for prevention or treatment of Parkinson's Disease (PD). T