| dc.description.abstract | Background: Upper respiratory tract infections, one of which is pharyngitis, is increasing worldwide caused by
infection with the Streptococcus pyogenes bacteria. The sambungnyawa has been tested, and the results can be used as an antioxidant and antibacterial because it has phenolic and flavonoid compounds Materials and Methods:The purpose of this study was to examine the antioxidant and antibacterial activity of 70% ethanol extract, ethyl acetate extract and sambungnyawa chloroform extract. The method used to test the antioxidant activity was the DPPH method, and the antibacterial activity test using microdilution was performed on Streptococcus pyogenes bacteria. Results: The results obtained showed that the IC50 values of 70% ethanol extract, ethyl acetate extract and sambungnyawa chloroform extract had antioxidant activity values, respectively, namely 135.0479; 116.8404; 122.1700. The total phenol and flavonoid content of 70% ethanol extract, ethyl acetate and chloroform were 23.73 ± 0.33 %, respectively; 37.42 ± 2.07%; 23.12 ± 0.93% and 0.98 ± 0.04%; 7.28 ± 0.12 %; 9.57 ± 0.33%. All sambungnyawa extracts had MIC at a concentration of 256 ppm.Conclusion:Based on the results of the study, it can be concluded that the sambungnyawa extract has the
highest antioxidant activity in ethyl acetate extract, the highest total phenolic content, namely ethyl acetate
extract and total flavonoid content, namely chloroform extract, and can inhibit the growth of Streptococcus
pyogenes bacteria. | en_US |
