| dc.description.abstract | HMG-CoA (3-hydroxyl-3-methyl-glutaryl-coenzyme A) reductase is a liver enzyme that plays an important role in the process of cholesterol synthesis in the liver. Statins are one of the major drug classes for lowering cholesterol through inhibition of HMG-CoA reductase enzyme activity. This study aims to determine the effect of Zingiber cassumunar Roxb ethanol extract as anti-hyperlipidemia and its effect on HMG-CoA reductase enzyme in the liver. A total of 30 white Wistar rats were grouped randomly into 6 groups: group 1 (receiving drug carrier), group 2 receiving drug carrier), group 3 (receiving simvastatin 0.9 mg / kg), group 4-5 (receiving extract dose 30, 50, and 100 mg / kg). All groups (except group 2) received 25% fructose in drinking water for 21 days. Day 22 was taken by blood for examination of total cholesterol, HDL, LDL, and triglyceride levels. Then the rats were sacrificed for liver organ isolation and made homogenate liver 20% for HMG CoA reductase
enzyme activity test. The results showed that ethanol extract of Zingiber cassumunar Roxb dose 30, 50, and 100 mg / kg can decrease total cholesterol, triglyceride, LDL and increase HDL level compared to control group. Extracts of doses of 30, 50, and 100 mg / kg can inhibit the activity of HMG CoA reductase enzyme with a percentage of 11, 20, and 47% inhibition respectively. The results can be concluded that Zingiber cassumunar Roxb has anti-hyperlipidemia activity. One of the mechanisms of action is by inhibiting the activity of HMG CoA reductase enzyme. | en_US |
